Stereochemistry

Contents: Preface. 1. Stereochemistry. 2. Stereoisomers. 3. Alkene Stereoisomers. 4. Cycloalkane stereoisomers. 5. Conformational isomerism. 6. Stereoisomers. 7. Symmetry elements. 8. Atropisomer. 9. Cis-Trans Isomerism. 10. Conformational isomerism. 11. Diastereomer. 12. Enantiomer. 13. Alkane Stereochemistry. 14. Chirality (Chemistry). 15. Stereocentre. 16. Dynamic stereochemistry. 17. General discussion. 18. Graphical representation of Non-Planar Molecules. 19. Interaction of drugs with biological matrices. 20. Rules for specification of Chirality. 21. Some more concepts of Stereochemistry. Glossary.

"This short text covers the fundamental principles in all aspects of stereochemistry. This concise resource is generously enriched with numerous worked examples. Concentrating on organic chemistry, early chapters in this resourceful publication deal mainly with definition of terms such as chirality, enantiomers, diastereoisomers and racemisation, complete with suitable examples to illustrate key concepts. Use of a polarimeter and associated definitions are described, together with two different conventions D, L and R, S for specification of configuration. The distinction between conformation and configuration is developed to include assignment of configurations to di-substituted cyclohexanes and to the decalins.

This introductory text reviews molecular architecture, relating empirical bonding geometrics to hybridization of central carbon atom; classifies stereoisomers according to symmetry properties and to nature of their barriers; an explores conceptual basis of asymmetric syntheses and kinetic resolutions." (jacket)