Developments in Psychopharmacology
Contents: Foreword. Preface. 1. Y-Amino butyric acid receptor pharmacology: from concepts to application/S.K. Kulkarni. 2. Y-Amino butyric acid (GABA) mediated behavioral studies/S.K. Kulkarni and Ashish Dhir. 3. On the GABAergic actions of Withania somnifera: an Indian ginseng/S.K. Kulkarni. 4. Effect of cyclooxygenase-2 (COX-2) inhibitors in various animal models (bicuculline, picrotoxin, maximal electroshock-induced convulsions) of epilepsy with possible mechanisms of action/Ashish Dhir, P.S. Naidu and S.K. Kulkarni. 5. Motor and electrograhic response of refractory experimental status epilepticus in rats and effect of calcium channel blockers/B. George, S.K. Kulkarni and R. Mathur. 6. Studies on anticonvulsant actions of L-deprenyl./Manu Gupta and S.K. Kulkarni. 7. Pentylenetetrazol-induced kindling in animals: protective effects of BR-16A/S.K. Kulkarni and B. George. 8. Altered response to GABAergic agents following electro and chemo convulsions in mice/K.O. Aley and S.K. Kulkarni. 9. Effect of chronic treatment of Ro 15-1788 and its withdrawal on cortical and hippocampal EEG activity in rats/K.O. Aley, S.K. Kulkarni, R. Mathur and U. Nayar. 10. Benzodiazepine inverse agonist, DMCM- and peripheral agonist, Ro 5-4864- induced convulsions in mice: effect of adenosinergic agents/S.N. Thorat and S.K. Kulkarni. 11. Effect of NMDA-receptor ligands on neocortical and hippocampal EEG activity of rat brain/Avadesh C. Sharma, S.K. Kulkarni and Usha Nayar. 12. On the convulsant action of DMCM and Ro 5-4864 in mice/Joseph Kunchandy and S.K. Kulkarni. 13. Autonomic hyperactivity in diazepam withdrawal in rats/Joseph Kunchandy and S.K. Kulkarni. 14. Central nervous system depressant activities of melatonin in rats and mice/A.V. Shaji and S.K. Kulkarni. 15. Reversal of diazepam withdrawal induced hyperactivity in mice by BR 16-A (Mentat®), herbal preparation/S.K. Kulkarni and Alok Sharma. 16. Protective effect of BR-16A (Mentat®), a herbal preparation on alcohol abstinence-induced anxiety and convulsions/S.K. Kulkarni and Anita Verma. 17. Alprazolam modifies animal behavior on elevated plus-maze/S.K. Kulkarni and Komal Sharma. 18. Prevention of development of tolerance and dependence to opiate in mice by BR-16A (Mentat®), a herbal psychotropic preparation/S.K. Kulkarni and Anita Verma. 19. Effect of herbal psychotropic preparation, BR-16A (Mentat®), on performance of mice on elevated plus-maze/Anita Verma and S.K. Kulkarni. 20. Effect of reserpine, chlorpromazine and meprobamate on stress induced metabolic alterations in urinary excretion of 3-methoxy-4-hydroxymandelic acid/S.K. Kulkarni, P.C. Dandiya and K.P. Khuteta. 21. Basic mechanisms of pain and inflammation: regulators and their inhibitors/S.K. Kulkarni and Vijay Pal Singh. 22. Potentiation of antinociceptive effect of NSAIDs by a specific lipoxygenase inhibitor, acetyl-11-keto-beta-bosewellic acid/Mahendra Bishnoi, C.S. Patil, Anil Kumar and S.K. Kulkarni. 23. Role of cyclooxygenase-2 in lipopolysaccharide-induced hyperalgesia in formalin test/S.S.V. Padi and S.K. Kulkarni. 24. Effect of licofelone against NSAIDs-induced gastrointestinal ulceration and inflammation/Vijay Pal Singh, C.S. Patil and S.K. Kulkarni. 25. Possible analgesic and anti-inflammatory interactions of aspartame with opioids and NSAIDs/Sameer Sharma, N.K. Jain and S.K. Kulkarni. 26. Cholinergic-NO-cGMP mediation of sildenafil-induced antinociception/C.S. Patil, Naveen Jain, Vijay Pal Singh and S.K. Kulkarni. 27. Effect of 5-lipoxygenase inhibition on events associated with inflammatory bowel disease in rats/Vijay Pal Singh, C.S. Patil and S.K. Kulkarni. 28. D2-dopamine receptor and a2-adrenoceptor-mediated analgesic response of quercetin/P.S. Naidu, Amanpreet Singh and S.K. Kulkarni. 29. Antinociceptive actions of FK-506 in mice/Amanpreet Singh, Gaurav Kumar, P.S. Naidu and S.K. Kulkarni. 30. Analgesic and anti-inflammatory effects of phosphodiesterase inhibitors/Anil Kumar, Naveen K. Jain and S.K. Kulkarni. 31. Involvement of dopamine d2 and 5-HT1A receptors in roxindole-induced antinociception/Ipe Ninan and S.K. Kulkarni. 32. Antinociceptive effects of sumatriptan in mice/N.K. Jain and S.K. Kulkarni.
"Psychoneuropharmacological research has received special attention during the last four decades particularly after the discovery of psychotropic drugs, chlorpromazine and reserpine. These drugs have not only helped in alleviating many mental disorders but also have helped neuroscientists to look deeply into the neurotransmitter based pathophysiology of the mental diseases. Of the many neurotransmitters which are involved in the behavioral effects of drugs, gamma amino butyric acid (GABA) and dopamine have received a great attention. Gamma amino butyric acid, the major inhibitory neurotransmitter ubiquitously distributed in the central nervous system modulates many neurodegenerative diseases such as epilepsy, memory deficits, stress and anxiety. The book is based on the research work conducted by the author in these areas, interestingly all these research papers emanating from the work that have been published in one single journal namely, IJEB. The author has written about the current developments in GABA receptor pharmacology and behavioral disorders and these articles are supported by selected publications from IJEB which are put in the form of book format for easy reference.
Another hot area in psychopharmacology is the study of pain and pain related disorders. Again the book carries selected articles on pain and inflammation published by the author in IJEB. The book is unique in its format as it carries four important conceptual articles supported by as many as 28 of his own research articles from IJEB which makes the reader not only easy to follow but actually helps him/her in knowing the details of the experimental protocols as the research papers are also incorporated. The book is a valuable addition for postgraduate and doctoral researchers in psychobiology, physiology, pharmacology and related basic medical sciences." (jacket)
