Screening Methods in Pharmacology, Vols. I and II

Contents: Vol. I: Preface. 1. Introduction. 2. A brief review of the biochemistry of the nervous system. 3. The organization of screening. 4. General methods. 5. Quantal responses. Calculation of the ED50. 6. Depressants of the central nervous system. 7. Ataractic (Tranquillizing, Neuroleptic) agents. 8. Analgesics. 9. Oxytocic agents. 10. Antiserotonin agents. 11. Parasympatholytic agents. 12. Sympatholytic agents. 13. Anti-inflammatory agents. 14. Anticonvulsants. 15. Sympathomimetic agents. 16. Central stimulants. 17. Muscaring agents. 18. Ganglion-blocking agents. 19. Antifibrillatory agents. 20. Cardiotonic agents. 21. Histamine-like agents. 22. Antihistamine agents. 23. Antitussive agents. 24. Antacid agents. 25. Thyromimetic agents. 26. Hypoglycemic agents. 27. Choleretic agents. 28. Antiparkinson agents. 29. Anti-inflammatory and glucocorticoidal agents. 30. Antiemetic agents. 31. Bronchodilatant agents. 32. Curariform agents. 33. Anabolic, Androgenic and Antiandrogenic agents. 34. Potentiators and antagonists of tryptamine. 35. Vasopressive peptides. 36. Diuretic and natriuretic agents. 37. Anticholinesterase agents. 38. Anticholesterol agents. 39. Uricosuric agents. 40. Antishock agents. 41. Hemostatic agents. 42. Local and spinal anesthetics. 43. Abortificient agents. 44. Thymoleptic agents. 45. Dermal irritants. 46. Teratogenic agents. Appendixes. References. Author index. Subject index.

Vol. II: 1. a-Adrenergic blocking agents/V.C. Swamy. 2. b-Adrenergic blocking agents/Robert A. Turner. 3. Agents acting on coronary blood vessels/R. Kadatz. 4. Agents with Kinin-like activity/H.J. Wilkens and R. Steger. 5. Androgenic and anabolic agents/Peter Hebborn. 6. Estrogenic and antiestrogenic agents/Marian May. 7. Anovulatory agents/Marian May. 8. Progestational agents/Peter Hebborn. 9. Antihyperlipidemic agents/Jack N. Moss and Esam Z. Dajani. 10. Immunosuppressive agents/Robert L. Stone and Charles J. Paget. 11. Agents affecting Mucociliary Activity/Sam P. Battista. 12. Antiperspirant agents/Clyde M. Burnett. 13. Antidepressant agents/Allen Barnett and Robert I. Taber. 14. Agents with analgesic activity and dependence liability/Jerome M. Glassman. 15. Natriuretic and Antihypertensive agents screened by sequential methods/E. Gilliard, P.R. Hedwall and K. Mullen. Author index. Subject index.

From the Preface: "This book assembles most of the methods for screening substances for pharmacological activity and includes discussions of the organization of screening programs. While screening is widely practiced in pharmacology laboratories, a definition of its meaning is perhaps worthy of attention. The term screening indicates the use of a combination of tests for the purpose of making a decision. The results of the tests provide information on the presence of certain pharmacological properties.

The present work is obviously directed to those whose occupation it is to search for new pharmaceuticals. A variety of investigators in the fields of pharmacology, physiology, toxicology, and therapeutics may also find useful methods for their research. Chemists in the pharmaceutical industry who read this book will be aided in their understanding of the basis for testing the compounds that they synthesize and in their understanding of the programs for testing that the pharmcologist has devised." (jacket)